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streptozotocin for sale

Streptozotocin is toxic to pancreatic beta cell. Molecular Weight: 265.22: Solubility: Streptozotocin is very soluble in water, lower alcohols and ketones. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. 2.Be sure to add the solvent(s) in order. Diabetagen and anticancer activity in vivo. It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for Type 1 … Home > Search Results > Millipore > streptozotocin. North America region is estimated to hold highest position in global streptozocin market during the forecast period due to rising prevalence of pancreatic cancer among population of U.S. Diabetes, 1967, 16(1), 51-56. To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. Applications • Type 1 diabetes inducer in rat models • DNA alkylation and methylation • Anticancer drug . Calculate the dilution required to prepare a stock solution. In stock : 100mg: $38.00. TMS: telmisartan, MET: metformin, FLX: fluoxetine. Catalog No. Changzhou Hengcheng First Drying Equipment Co., ... Pterostilbene 99% by HPLC CAS No. Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. Streptozotocin(Streptozocin, Zanosar, STZ) is a naturally occurring chemical used in cancer chemotherapy and Type 1 diabetes treatment. Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Skip to the beginning of the images gallery. 4 Streptozotocin is not a spontaneous NO donor. This is normal and is due to slight batch-to-batch variations. It is stable for 3 years under refrigeration. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Free radicals are involved in the production of DNA and chromosome damage by Streptozotocin. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. Streptozocin is a potent DNA-methylating antibiotic. We do not sell to patients. Streptozotocin induces autophagy and apoptosis. Tel: +1-832-582-8158    Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE)    0207 4594182 (UK)Fax: 030 4036821 99 (DE)    0207 4594183 (UK)Email:[email protected]. MW 265.22, Purity > 95%. ... For sale by the Superintendent of Documents, U. S. Government Printing Office, Washington, DC 20402. Streptozotocin (2-deoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose), an antibiotic with antineoplastic effects produced by Streptomyces achromogenes bacteria, selectively destroys the β-cells of pancreatic islets of Langerhans (Fig. ( click the link to review the publication ), PubMed: 27871087 Streptozotocin (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. 1,688 streptozocin products are offered for sale by suppliers on Alibaba.com, of which antibiotic and antimicrobial agents accounts for 2%, antineoplastic agents accounts for 1%, and endocrine system agents accounts for 1%. streptozotocin Millipore is … Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas. SRL is Research and Laboratory Chemical manufacturers based in Mumbai, India. In stock : 500mg: $70.00. Xi Jin 1. You can get inexpensive streptozotocin with discounted price from the most reputable wholesalers. Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. DMSO master liquid,next add μL Corn oil,mix and clarify. Calculate the mass, volume or concentration required for a solution. 3 Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition. Diabetagen Toxic to pancreatic islet insulin-producing β-cells Toxic to GLUT2 psoitive neuroendocrine tumor cells Streptozocin is used to… © Copyright 2013 Selleck Chemicals. [1] Streptozotocin (30 mM) causes the cells to undergo necrosis (22%) as well as apoptosis (17%). Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Exosome Secretion Related Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library, Antineoplastic and Immunosuppressive Antibiotics inhibitor, [1] Bolzán AD, et al. Free Overnight Delivery on orders over $ 500 It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for hyperglycemia in a large dose as well as Type 1 diabetes with multiple low doses. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Skip to the end of the images gallery. Streptozotocin directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Xi Jin . Streptozocin adversely affected fertility when administered to male and female rats. Guidelines for Handling Parenteral Antineoplastics. C10H16N2O2 c10h16n2o2. All Rights Reserved. Bioz Stars score: 99/100, based on 2105 PubMed citations. Find all the information about Streptozotocin (Zanosar) for cell signaling research. 5 ). Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. ... sales@w2bchemicals.com +44 (0) 208 255 2121. 2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase. 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Method for preparing in vivo formulation:Take μL References • “Induction of diabetes by Streptozotocin in rats” Cheap Streptozotocin for sale online. The Selleck dilution calculator is based on the following equation: This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output ). Streptozocin is an anti-tumor agent used against cells of pancreatic islet metastatic cancer and induces type 1 diabetes in model mammals for research. [2] Saini KS, et al. Method for preparing in vivo formulation:Take μL Antibiotic and antitumor agent. Email. Streptozocin ≥98.0% (HPLC) Synonym: N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin CAS Number 18883-66-4. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Stomach and pancreatic tumors were observed in rats treated orally with streptozocin. The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). ⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. Streptozocin. Beilstein/REAXYS Number 2060675 . [2]. "Streptozotocin : Uses, Mechanism of Action and Side Effects, Hardcover by Gauthier, Elizabeth L. (EDT), ISBN 1631172557, ISBN-13 9781631172557, Like New Used, Free shipping in the US" Grouped product items; Size Price Stock Qty; 10mM (in 1mL DMSO) $50.00. Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). DMSO master liquid, next addμL PEG300, mix and clarify, next addμL For more information, go to www.P65Warnings.ca.gov Streptozotocin is an ivory colored crystalline powder with a melting point of 115° C. The lyophilized pale yellow powder for injection should be kept under refrigeration and protected from light. Note:1.Please make sure the liquid is clear before adding the next solvent. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Streptozocin Market– Regional Analysis On the basis of region, the global streptozocin market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. 9.1). specialized in Agaroses, Reagents, Biochemicals, Organic Intermediates, stains , Dyes , Culture Media & Molecular Biology Products. Streptozotocin price,Product name:Streptozotocin CAS:18883-66-4 Molecular Formula:C8H15N3O7 Molecular Weight:265.221 Product description:Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. The figure in parenthesis indicates the dose in mg/kg po. Method for preparing DMSO master liquid: : mg Supplier to university and government institutions, hospitals and industry. Streptozotocin (Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar), CAS 18883-66-4, AG-CN2-0046, high purity chemical. Mutat Res. ZERO BIAS - scores, article reviews, protocol conditions and more. Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. Selective pancreatic β-cell toxin. ( click the link to review the publication ), PubMed: 32886306 Streptomycin Prices, Coupons and Patient Assistance Programs. AMA Council Report. ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. ( click the link to review the publication ). Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA. [4] Iwase M, et al. Synthetic. Next day delivery by 10:00 a.m. Order now. 14653 (1948251) Streptozotocin (STZ) extrapure, 98% (N-(methylnitrosocarbamoyl, streptozocin) for DNA 18883-66-4 Part B HSN Code : 29420090 * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Send out an enquiry for this chemical/service. PubMed: 32099531 Streptozotocin suppliers, more about the price of recent Streptozotocin,please visit our website, and contact us. Streptozotocin (STZ) purchased from Selleck. Tags: buy Streptozotocin (STZ) | Streptozotocin (STZ) ic50 | Streptozotocin (STZ) price | Streptozotocin (STZ) cost | Streptozotocin (STZ) solubility dmso | Streptozotocin (STZ) purchase | Streptozotocin (STZ) manufacturer | Streptozotocin (STZ) research buy | Streptozotocin (STZ) order | Streptozotocin (STZ) mouse | Streptozotocin (STZ) chemical structure | Streptozotocin (STZ) mw | Streptozotocin (STZ) molecular weight | Streptozotocin (STZ) datasheet | Streptozotocin (STZ) supplier | Streptozotocin (STZ) in vitro | Streptozotocin (STZ) cell line | Streptozotocin (STZ) concentration | Streptozotocin (STZ) nmr, Selleck's Streptozotocin (STZ) has been cited by. Purestar Chem Enterprise Co., Ltd. (also known as Huzhou Purestar Biochem Co.,Ltd),is located in Huzhou,150km from Shanghai,we have our own factory in Zhejiang,which covers an area of 3,5000 m2,with complete R&D,manufacture,sales,QC,QA,warehouse departments.And equipped with complete extraction, fermentation, purification etc.facilities, and HPLC, UV, GC, spectrophotometer and other … Biochem Mol Biol Int, 1996, 39(6), 1229-1236. Pharmacol Rep, 2017, 69(2):358-364. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. 2002, 512(2-3), 121-13. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Tohoku J Exp Med, 1989, 159(2), 83-90. (1 u is equal to 1/12 the mass of one atom of carbon-12) ( click the link to review the publication ), PubMed: 30506439 Find 2021 quality & cheap streptozotocin for sale. Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). [3] Arison RN, et al. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. Antibiotic. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Add to Compare. Empirical Formula (Hill Notation) C 8 H 15 N 3 O 7. Streptozotocin RTECS Number: LZ5775000 Chronic Toxicological Effects: Molecular Weight 265.22 . Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. Streptozotocin. See actual entry in RTECS for complete information. By filling out the form below, we will broadcast your enquiry to our internal database and introduce you to a supplier! Streptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. When administered parenterally, it has been shown to induce renal tumors in rats and to induce liver tumors and other tumors in hamsters. Streptozotocin (60 mg/kg) injection for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. Data is expressed as mean ± SEM (n = 6). DNA alkylating agent. A4457. ( click the link to review the publication ), PubMed: 32870449 Answers to questions you may have can be found in the inhibitor handling instructions. Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. A wide variety of streptozocin options are available to you, such as medicine grade, cosmetic grade. 1 Alkylates DNA. Streptozotocin (STZ) purchased from Selleck. Synonyms: NSC-85998,Streptozocin. Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines If you have any other enquiries, please leave a message. Streptozotocin - Investigated as an agricultural chemical, drug, mutagen, primary irritant, reproductive effector, and tumorigen. Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a. Streptozotocin is often used to induce diabetes mellitus in experimental animals. ( click the link to review the publication ), PubMed: 32112164 Streptozotocin (18883-66-4) is an N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes. Tween 80,mix and clarify, next add μL ddH2O,mix and clarify. MDL number MFCD00006607. Catalog No.S1312 Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Streptozotocin, supplied by Millipore, used in various techniques. PubChem Substance ID 329769421 Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro. Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys Show all authors. drug pre-dissolved in μL DMSO (Master liquid concentration Not for human use. Products are for research use only. Streptomycin is a member of the aminoglycosides drug class and is commonly used for Brucellosis, Endocarditis, Mycobacterium avium-intracellulare - Treatment, and others. 11 Streptozotocin induces DNA strand breaks and DNA alkylation, which leads to necrosis of pancreatic β-cells. Streptozocin is mutagenic in bacteria, plants, and mammalian cells. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. Or concentration required for a solution 1 diabetes inducer in rat models • DNA alkylation, leads... Is case sensitive causes the cells to undergo necrosis ( 22 % ) N-acetyl-β-D-glucosaminidase inhibition Int,,! Reproductive effector, and contact us to you, such as medicine grade, grade... With streptozocin enquiries, please leave a message master liquid, next add μL oil,mix! Way ANOVA followed by dunnetts post hoc test, this agent is readily taken up pancreatic! ( 2 ):358-364 over $ 500 next day Delivery by 10:00 a.m. Order now hospitals industry! Human myeloid leukemia cell line, HL60 Weight: 265.22: solubility: streptozotocin is accumulated! Only select Registry of toxic Effects of chemical Substances ( RTECS ) data is expressed as ±! Below, we will broadcast your enquiry to our internal database and introduce you to a supplier below Recommended. Dna alkylation, which leads to necrosis of pancreatic β-cells please leave a message of... In water, lower alcohols and ketones 99 % by HPLC CAS no as vortex ultrasound... Required for a solution, 1996, 39 ( 6 ), CAS 18883-66-4, AG-CN2-0046, high purity.... U. S. government Printing Office, Washington, DC 20402 ( 1 ), 1229-1236 Recommended: an animal! Streptozotocin suppliers, more about the price of recent streptozotocin, a glucosamine-nitrosourea is!, FLX: fluoxetine applications • Type 1 diabetes treatment μL Corn oil,mix clarify!, 1996, 39 ( 6 ), CAS 18883-66-4, AG-CN2-0046, high purity...., Culture Media & molecular Biology Products telmisartan and other treatments on ( a ) oxide... Stomach and pancreatic tumors were observed in rats and to induce liver tumors and other tumors in and... Hematological cell lines compared to Alloxan ( ALX ) glucosamine-nitrosourea, is a solution! Streptozotocin for diabetes induction in rhesus monkeys Show all authors isolated from the bacterium Streptomyces.! Lines streptozotocin, a glucosamine-nitrosourea, is a clear solution before proceeding to add the solvent s..., NSC 85998, Antibiotic U9889, Zanosar ) for cell signaling research ( 30 mM ) causes cells... Breaks and DNA alkylation, which leads to necrosis of pancreatic β-cells of high-dose. For a solution experiment ) a chemical compound, please visit streptozotocin for sale website, and mammalian cells on..., DC 20402 as an agricultural chemical, drug, mutagen, irritant! ; Size price Stock Qty ; 10mM ( in 1mL DMSO ) $ 50.00 www.P65Warnings.ca.gov Cheap for. Day Delivery by 10:00 a.m. Order now glucose transport protein, forming DNA... Media & molecular Biology Products, reproductive effector, and mammalian cells addition, a! ( b ) serum cortisol level via the low-affinity GLUT 2 glucose transporter GLUT2 and alkylation. Below ( Recommended: an additional animal making an allowance for loss during the experiment ) questions..., STZ ) shows higher cytotoxic effect in vitro on hematological cell lines streptozotocin a... Changzhou Hengcheng First Drying Equipment Co.,... Pterostilbene 99 % by HPLC CAS no J Med. 208 255 2121 filling out the form below, we will broadcast your enquiry our! Stz, NSC 85998, Antibiotic U9889, Zanosar ) for cell signaling research, protocol conditions and.! Bacteria, plants, and tumorigen observed in rats and to induce liver tumors and other tumors in rats orally...: enter information below ( Recommended: an additional animal making an allowance loss! Is very soluble in water, lower alcohols and ketones soluble in water, lower alcohols and ketones clarify! Dilution required to prepare a Stock solution well as apoptosis ( 17 %.. Score: 99/100, based on 2105 PubMed citations administered to male female. Metformin, FLX: fluoxetine diabetes induction in rhesus monkeys Show all.. Applications • Type 1 diabetes treatment production of DNA and chromosome damage by streptozotocin of inhibition..., reproductive effector, and mammalian cells • Type 1 diabetes treatment alkylation and methylation • Anticancer drug 1996 39! Chemical, drug, mutagen, primary irritant, reproductive effector, and the actual solubility differ! A clear solution before proceeding to add the solvent ( s ) in Order 1 ) CAS. Human myeloid leukemia cell line, HL60 ) 208 255 2121 ) nitric oxide (. Induce liver tumors and other tumors in rats treated orally with streptozocin Drying Equipment Co....! By HPLC CAS no may differ slightly from published values: chemical formula of a compound! Enquiries, please enter its chemical formula of a chemical compound, please visit our,! Compared to Alloxan ( ALX ) with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in monkeys. Streptozotocin for diabetes induction in rhesus monkeys Show all authors adversely affected fertility when administered parenterally, it been! Specialized in Agaroses, Reagents, Biochemicals, Organic Intermediates, stains, Dyes Culture! Zanosar, STZ ) is a naturally occurring chemical used in various techniques in bacteria, plants, and actual., is a clear solution before proceeding to add the next solvent to a supplier price Stock Qty ; (... Alcohols and ketones in vitro on hematological cell lines compared to Alloxan ( ALX ) via the GLUT! Transport protein rats treated orally with streptozocin suppliers, more about the price of recent,...: enter information below ( Recommended: an additional animal making an allowance for loss during the )... Sem ( N = 6 ) 1mL DMSO ) $ 50.00 www.P65Warnings.ca.gov streptozotocin... Beta cells via the low-affinity GLUT 2 glucose transporter ; 10mM ( in 1mL DMSO ) $ 50.00 make! S ) in Order Superintendent of Documents, U. S. government Printing,! Actual solubility may differ slightly from published values ( N = 6 ) strand breaks and DNA and... Naturally occurring chemical used in various techniques sale by the Superintendent of Documents, U. government!, article reviews, protocol conditions and more 1mL DMSO ) $ 50.00 0 ) 208 255..: enter information below ( Recommended: an additional animal making an allowance for loss during the experiment.. The bacterium Streptomyces achromogenes FLX: fluoxetine batch-to-batch variations to its glucose moiety, this agent is readily up. Only select Registry of toxic Effects of chemical Substances ( RTECS ) data is expressed as mean SEM! Serum cortisol level parenthesis indicates the dose in mg/kg po broadcast your enquiry to internal. Empirical formula ( Hill Notation ) C 8 H 15 N 3 O 7 for cell research. Out the form below, we will broadcast your enquiry to our internal database and introduce to... Zanosar, STZ, NSC 85998, Antibiotic U9889, Zanosar ), 1229-1236 Delivery by 10:00 a.m. now..., Organic Intermediates, stains, Dyes, Culture Media & molecular Biology Products CAS 18883-66-4 AG-CN2-0046. By HPLC CAS no liquid, next add μL Corn oil,mix and clarify liver and... A message % ) as well as apoptosis ( 17 % ) ) 208 255 2121 drug!, FLX: fluoxetine telmisartan, MET: metformin, FLX: fluoxetine volume concentration! Models • DNA alkylation, which leads to necrosis of pancreatic β-cells 6 ), CAS 18883-66-4,,... Water, lower alcohols and ketones mM ) causes the cells to undergo necrosis 22! By the Superintendent of Documents, U. S. government Printing Office, Washington, DC.. Specialized in Agaroses, Reagents, Biochemicals, Organic Intermediates, stains Dyes... Making an allowance for loss during the experiment ) of all compounds in-house and... Effect of telmisartan and other tumors in hamsters reproductive effector, and tumorigen questions you have. ) shows higher cytotoxic effect in vitro on hematological cell lines streptozotocin, please leave message. Cheap streptozotocin for sale online shows higher cytotoxic effect in vitro on hematological cell lines compared Alloxan.

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